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Mutation in Structure of Proteins Affects AIDS Immunity


Submitted by Cindy Tweed on Tue, 12/28/2010 - 09:46 Health TNM
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Some HIV infected people do not develop AIDS as certain mutations in proteins in their body help destroying infected cells, according to a recent study appeared in Nature.

The clinical worth of the HIV controllers was realized by Bruce Walker of the Harvard University in Charlestown, one who led the study. From the genetic analysis of the protein, it was found that alternations in the structure of a protein encourage immune system to identify and damage infected cells.

When the HIV virus reproduces in the cells of the infected persons at considerably high levels, they get affected with AIDS and their immune system starts weakening. One out of every 300 HIV infected people, the virus doesn't replicate as this mutation gets suppressed by the body.

The team led by Walker performed analysis on the DNA of more than 900 HIV controllers and then using a technique called a genome-wide association study (GWAS) compared the genetic code of 2,600 HIV infected individuals. Employing the procedure, the researchers examined single nucleotide polymorphism (SNP) variations. It was discovered that there were over 300 locations, which were related to controlling HIV.
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