LIMK scoperto nuovo enzima di cui si serve l' Hiv Aids

Ricercatori statunitensi hanno scoperto un enzima LIMK (LIM domain kinase), di cui si servirebbe il virus Hiv per infettare le cellule T, anche se il processo non e' ancora del tutto chiaro, ma si e' scoperto che se si inibisce in laboratorio tale enzima l'Hiv non e' piu in grado di infettare le cellule T.
Ora si spera di trovare farmaci che inibiscano tale enzima.

Enzyme Helps HIV Infect T Cells

A researcher at Georgetown University who previously discovered a protein that cuts the outer layer of T cells to promote HIV infection has discovered an enzyme that does the same thing but in a different way. The enzyme, LIM domain kinase (LIMK) moves like a propeller and is required by the virus to infect T cells. Experiments in which LIMK was activated by a compound led to an increase in the infection of T cells so they hypothesize that decreasing its activity will. T cells that were created in the lab to inhibit LIMK activity were not infected with HIV as easily as cells from a donor. It is hoped that LIMK inhibitors can be developed and believe that drug resistance would not be a major issue in targeting this enzyme.

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